![]() By acting as a circulating decoy for interleukin-33 (IL-33), it prevents the cardioprotective effects of the ST2/IL-33 signaling, thus promoting maladaptive myocardial hypertrophy and cardiomyocyte apoptosis. sST2 is mainly produced in extracardiac tissues in response to proinflammatory and profibrotic stimuli. Among them, soluble suppression of tumorigenesis-2 (sST2), a member of the interleukin 1 receptor family, emerged as an efficient prognostic biomarker for patients with chronic HF. Though the cardiac-specific biomarkers brain natriuretic peptide (BNP) and cardiac troponins (cTn) are firmly established as cornerstones of the diagnosis of heart failure (HF) and myocardial injury, respectively, a growing body of evidence supported the role of several non-cardiac specific biomarkers in describing the most relevant pathophysiological features of HF, i.e., inflammation, oxidative stress, extracellular matrix remodeling, neurohormonal activation, myocyte injury and stress. While their assessment has been shown to invariably improve the discrimination and reclassification of the risk of developing endpoints such as major adverse CV events (MACE), there is still uncertainty on whether their serial measurement may be useful to predict CV mortality or the cardioprotective benefits of T2DM medications. More recently, a role for cardiac biomarkers has been advocated in the setting of CV outcome trials in T2DM. Ī large body of evidence was published on the associations of single biomarkers with CV risk in T2DM, but simultaneous evaluations of large numbers of biomarkers in diabetic populations have been limited. Risk models for use in individuals with diabetes typically do not include information from biomarkers other than cholesterol, glycated hemoglobin (HbA1c), and urinary albumin-to-creatinine ratio (UACR), raising the question of whether adding novel biomarkers would improve CV risk prediction in patients with T2DM. The long-term prognostic value of sST2 and its ability to track variables related to insulin resistance and associated metabolic disorders support its implementation into routine clinical practice.Ĭurrent epidemiologic data have demonstrated that type 2 diabetes (T2DM) is accompanied by a 2–4-fold greater overall risk of cardiovascular (CV) complications compared to non-diabetic patients, even after adjustment for traditional risk factors. SST2, hs-cTnI, and NT-proBNP are associated with 15-year mortality and onset of CV events in T2DM. A ‘cardiac score’ based on the combination of sST2, hs-cTnI, and NT-proBNP was significantly associated with all-cause mortality (HR 1.35, C-statistic = 0.739) and development of CV events. SST2 followed an increasing trend from CTR to uncomplicated T2DM patients (T2DM-NC) to patients with at least one complication (T2DM-C), while hs-cTnI was significantly higher in T2DM-C compared to CTR but not to T2DM-NC. Their association with all-cause mortality and the development of diabetic complications was tested in T2DM patients over a median follow-up of 16.8 years using Cox models and logistic regressions. Serum levels of soluble suppression of tumorigenesis 2 (sST2), high-sensitivity (hs)-cTnI, and N-terminal (NT)-proBNP were assessed in 568 patients with T2DM and 115 healthy controls (CTR). Beyond the established role of brain natriuretic peptide (BNP) and cardiac troponins (cTn), other non-cardiac-specific biomarkers are emerging as predictors of CV outcomes in T2DM. ![]() Patients with type 2 diabetes (T2DM) present an increased risk of cardiovascular (CV) disease and excess CV-related mortality.
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![]() Ultra-rare RTEL1 gene variants associate with acute severity of COVID-19 and evolution to pulmonary fibrosis as a specific long COVID disorder ![]() ![]() Bermejo-Martin, Antoni Torres & Ferran Barbé Añón, Ana Loza-Vázquez, Nieves Carbonell, Judith Marin-Corral, Ruth Noemí Jorge García, Carmen Barberà, Adrián Ceccato, Laia Fernández-Barat, Ricard Ferrer, Dario Garcia-Gasulla, Jose Ángel Lorente-Balanza, Rosario Menéndez, Ana Motos, Oscar Peñuelas, Jordi Riera, Jesús F. García-Hidalgo, Thalia Belmonte, Carlos Rodríguez-Muñoz, Jessica González, Gerard Torres, Clara Gort-Paniello, Anna Moncusí-Moix, Ángel Estella, Luis Tamayo Lomas, Amalia Martínez de la Gándara, Lorenzo Socias, Yhivian Peñasco, Maria Del Carmen de la Torre, Elena Bustamante-Munguira, Elena Gallego Curto, Ignacio Martínez Varela, María Cruz Martin Delgado, Pablo Vidal-Cortés, Juan López Messa, Felipe Pérez-García, Jesús Caballero, José M. Benítez, Manel Perez-Pons, Nadia García-Mateo, Alicia Ortega, Tamara Postigo, María C. Siegel, Alexander Maier, Sarolta Bojtine Kovacs, Laszlo Kardos, Zoltan Csanádi, Marina Rieder, Daniel Duerschmied, Achim Lother, Christoph Bode, Gabor Tamas Szabó & Daniel CzurigaĪ blood microRNA classifier for the prediction of ICU mortality in COVID-19 patients: a multicenter validation studyĭavid de Gonzalo-Calvo, Marta Molinero, Iván D. Istvan Bojti, Anne-Sophie Przewosnik, Hendrik Luxenburger, Maike Hofmann, Christoph Neumann-Haefelin, Jennifer S. New articles will be added on a monthly basis.ĭecreased level of serum NT-proCNP associates with disease severity in COVID-19 To help keep our readers up-to-date on research and analysis related to the COVID-19 pandemic, we have created this collection of articles and other resources published in Respiratory Research. Gerd Leonhard | Futurist | Author | Speaker » New podcast: discussing chapter 2 of Gerd Leonhard’s book ‘Technology vs.Latest stories from our speakers | Speakers Associates on The age of surveillance capitalism: are we pawns or chess-players?.I think we have to accept that this is a time of permanent transition and perpetual VUCA (volatility. Latest stories from our speakers | Speakers Associates on Is Facebook unethical by design? A great case study on digital ethics, power, responsibility and regulation (via Monday Note) Dare to imagine a great American pivoting in 2021.Marc Andreessen’s “Why AI Will Save the World”: A Reductionist, Self-Serving Ode to Singularity Former Contributor Gerd Leonhard focuses on the future of humanity and technology, digital ethics, artificial intelligence, future leadership and foresight.Artificial Intelligence and the Future of Human Work – Gerd Leonhard’s Keynote at Steering Education 2023 in Riga (complete video). ![]() Towards the Good Future: A powerful new podcast episode with Futurist Gerd Leonhard, for Singularity University. ![]()
Vikki Blake of Eurogamer called the game surprisingly scary for something she initially thought was made for kids, saying that the game ran well on Stadia besides one crash. He praised the "cartoonish" character designs and "unnerving" soundtrack. Chris Shive of Hardcore Gamer rated the game 3/5 points, calling it an "enjoyable" game with a " Silent Hill vibe", but not a killer app. He called the story a "slow burn", while comparing the stealth mechanic to Metal Gear Solid, and remarked that using the flashlight as a weapon was a "cool" way to avoid using guns. Ĭhris Carter of Destructoid rated the game 7/10 points, calling it short, but mostly engaging. The game received an aggregate score of 68/100 on Metacritic, indicating "mixed or average" reviews. The man then disappears, leaving the teddy bear behind. They thank the old man and Emily gifts him her teddy bear before they use the cable car to return to the real world. ![]() He uses them to create a second ticket, allowing both girls to return to the real world. If Sally helped free all the imprisoned inhabitants throughout the game, the man discovers the scraps of paper that she received from the freed inhabitants, which are from the real world.Emily returns to school as posters of Sally are now seen on display around school. The nightmare world disappears, taking Sally with it. If Sally chooses to save Emily, she hands Emily her ticket and forces her into the cable car, remaining behind as monsters converge on her and the man.Feeling guilty, she continues to hang posters of Emily despite knowing what happened to her. If Sally chooses to save herself, she leaves Emily behind and escapes back to the real world alone as monsters converge on Emily and the man.Sally must decide who should remain behind. As they return to the cable car station, the old man reveals that they each need a ticket in order to leave the nightmare world and they only have one. ![]() With the help of the old man, Sally rescues Emily, who reconciles with her. Once Sally finds Emily, she expresses hatred towards Sally for not helping her in the past when she was bullied before being captured by a giant monster and taken to the mine. ![]() She finds Emily there along with a mysterious old man who urges her to help Emily. After school bullies cause her to crash her bike, she boards a cable car and enters a nightmare world full of monsters with dark parallels to her bullying. She has been hanging posters of Emily around town. The game's main character is Sally, a young girl who is trying to find her missing cousin, Emily. The game includes light elements of puzzles and combat. Sally uses a flashlight as a weapon, although she later acquires a fire extinguisher as well. The gameplay revolves around sneaking past enemies while trying to escape the nightmare. Gylt received mixed reviews from critics, who called it enjoyable and praised the graphics, but said that it lacked excitement. It received a multiplatform re-release on July 6, 2023. It was notable for being one of the few Stadia-exclusive titles, causing it to be temporarily unavailable for sale upon that platform's shutdown in 2023. It was released on Novemfor Google Stadia. Gylt is a survival horror video game developed and published by Tequila Works. PlayStation 4, PlayStation 5, Xbox One, Xbox Series X/S, Windows. ![]() Implementation '3:logging-interceptor:3.3. Implementation '2:converter-scalars:2.3.0' I have used those versions of retrofit and OkHttp in my existing android app and I found in logcat that there are lots of memory leaks as it says 'do you forget to close OkHttp as it has got memory leaks.' // ok http ' Builder.I faced this problem in one of my existing android apps A connection to myapicall was leaked. Sub EventName_onProgressUpdate (Progress As Float,uploaded As Float,total As Float) 'Request Body Should be a ProgressRequestBodyObservable ![]() Sub EventName_onSucess (key As String,path As String,Name As String,FileSize As Long) Sub EventName_onProgress (key As String,progress As Int,downloadedsize As Long,totalsize As Long) In this article, we're going to explain how to use Retrofit, with a focus on its most interesting features. Sub EventName_onResponse (Call As Amir_CallBack,Response As Amir_RetrofitResponse,Body As Amir_ResponseBody) Call is Retrofit's mechanism for executing network requests synchronously (via execute()) or asynchronously (via enqueue(Callback)). Overview Retrofit is a type-safe HTTP client for Android and Java developed by Square ( Dagger, Okhttp ). Room provides support for the following RxJava 2 return types: For one-shot queries, Room 2. ![]() Sub EventName_onFailure (Call As Amir_CallBack,Message As String) If your app uses the Java programming language, you can use specialized return types from the RxJava framework to write asynchronous DAO methods. Sub EventName_onNext (ResponseBody As Amir_ResponseBody) Sub EventName_onError (Error As String,Code As Int) However, when you first get started with these libraries it can be very difficult to understand how to implement them in your application (Working with Amir_Retrofit will be so much easy ).Īt first, I am telling you, do not stop using RxJava it's really awesome.īut if you don't want it, simply you can use Amir_RetroMin (RetroMin is just Retrofit Without RxJava and using default CallBack) or just use. RxJava2 and Retrofit2 are very powerful libraries that solve this problem. Loading data into an Android app can lag the UI thread if not done on a separate thread. This is a great feature because this way you should save your performances.ĪPI handling can be tedious if not completed in a good way. For example, Observables often don’t start emitting items until someone subscribes to them. And yes it is, but RxJava does it much better and has more options. Maybe some of you will think: „Hmmm this is so similar to standard Observable pattern“. Observable is used for emitting items and Subscriber is used for consuming those items. The building blocks of RxJava are Observables and Subscribers. RxJava is a Java VM implementation of ReactiveX a library for composing asynchronous and event-based programs by using observable sequences. Amir_Retrofit is using RxJava, but what is RxJava? Im able to fetch data using retrofit in android and able to set it view in recyclerView using adapter.but the thing is i dont want to fetch whole data from my api i want to remove some data from my api using java which should not be visible in recyclerview. Retrofit is strongly coupled with OkHttp and makes intensive use of it. In contrast, Retrofit is a high-level REST abstraction build on top of OkHttp. OkHttp is a pure HTTP/SPDY client responsible for any low-level network operations, caching, requests and responses manipulation.
![]() You can also transcribe another single speaker’s voice from pre-recorded audio files or from podcasts. Dictate into a digital voice recorder and Dragon will automatically transcribe the recordings when you connect to your desktop. Import and export custom word lists for acronyms or other unique business-specific terminologyĬreate custom voice commands for inserting frequently-used text and graphicsĬreate time-saving macros to automate multi-step workflows or business processes via simple voice commandsĭictate anywhere, transcribe back at your desktopĭon’t fall behind on reports and other documentation due to business travel. ![]() With advanced personalization features, like the ability to create custom commands and custom words, Dragon Professional Individual allows you to tailor it to the way you work for big productivity gains. Imagine saying “Insert Signature” and Dragon fills in your contact details, or dictating industry-specific terminology and Dragon types every word correctly-every time. Work more efficiently with powerful customizations Subscription is required for Dragon AnywhereĪdvanced customization and personalization Sync with Dragon Professional Individual, and work started on the road can be completed back at the desktop for seamless document workflows Import and export to and from popular cloud-based document-sharing tools like Dropbox® and note-taking apps like Evernote® Speak as long as you want to complete documents of any length-from a business report to an entire bookĮasily create form-based templates and fill out reports, such as client in-take forms-all in the moment And it syncs with Dragon Anywhere, the separate, cloud-based mobile dictation solution, letting you create and edit documents of any length by voice directly on your iOS or Android device for seamless productivity no matter where your job takes you. Dragon works with popular form factors such as portable touchscreen PCs. ![]() Keep up with documentation even on the road or out in the field. Work within popular business applications Smart Format Rules automatically adapt to how you want abbreviations, dates, phone numbers and more to appearĪpply formatting by voice, such as bold or underline Optimizes accuracy for speakers with accents or in slightly noisy environments such as an office cubicle Create documents and reports quickly and accurately, and zip through computer tasks in record time-all by voice.ĭragon learns the words and phrases you use the most to minimize corrections With a next-generation speech engine leveraging Deep Learning technology, Dragon adapts to your voice or environmental variations-even while you’re dictating. See how Dragon Professional Individual can help you get documents done faster and more accurately, both in and out of the office, so you can focus on revenue-generating tasks. With a next-generation speech engine leveraging Deep Learning technology, you can now dictate and transcribe faster and more accurately than ever before, and spend less time on documentation and more time on activities that boost the bottom line.Īs a business professional, you face heavy documentation demands each day. Put your voice to work to create reports, emails, forms and more with the all-new Dragon Professional Individual, v15. Dragon Professional Individual for documentation productivityĭrive documentation productivity-all by voice ![]() ![]() However, the biggest reason to get Kobo over other Epub readers is its store which allows you to browse and buy from over 5 million free and affordable eBooks, comics, and children’s books. The app brings all the usual features that we have come to expect from an Epub reader including, search, bookmarks, progress tracking, theming, and more, making it one of the best epub readers for Windows 11 that you can find. ![]() However, unlike Kindle, which doesn’t support Epub formats, Kobo does support both Epub and Epub 3 formats. Like Kindle, Kobo is not only an ebook reader app but a service which also allows you to buy books from its store. Supported Platforms: Windows 11, Windows 10, Windows 8, Windows 8.1 (ARM, x86, 圆4) Prosĭownload: Free with in-app purchases 6. On the other hand, if you are into comics and manga, there is no better app that you can get. So, if you are into books that feature a ton of images, Cover will be good for you. While all the other apps on the list can handle images, they can’t do it as well as Cover can. The app is packed with features allowing you to do things like downloading Epubs, managing metadata, downloading covers for books, transferring books from one device to another, and even converting books from one format to another. CalibreĬalibre is one of the oldest and the best Epub readers for your Windows 11 machine. So, you will need to install an app to open the Epub files. The older Edge browser supported the Epub files but the new Edge Browser that’s based-on-Chromium cannot open it. The process to open Epub files on Windows 11/Windows 10 is similar to opening a PDF file. In summation, an Epub reader is a program that allows you to read digital books on your computer, smartphone or any other electronic device. It’s a file format just like PDF, but XML-based so it has wide compatibility with programs from different platforms. In simple terms, a PC Epub Reader is a program that can open and process e-books (a digital version of a physical book). Read Ebooks in the Command Line with Epy. This includes employment advice and access to a peer-to-peer forum. Organise is free for anyone to join but also offers paid-for, enhanced support for those who need it.Īround 5% of users pay a subscription (usually £1 – £2 a week, depending on income) for enhanced support. Meanwhile, the business model is simple enough and, I’m told, is working. There are also whistleblowing platforms in existence, like Vault, which she points out is paid for by companies, “meaning it’s not ultimately in the interests or control of the workers.” On competitors, Whalley says Organise is the only platform empowering workers’ rights at scale. The dynamic nature of the tools we provide and the speed at which campaigns can get off the ground can be exactly what employees need to drive through meaningful change.” “For others, Organise makes it possible to bring colleagues together around a single issue where time is of the essence. “They use the Organise tools to enhance their impact and increase their reach,” she adds. No doubt helped by the coronavirus crisis and resulting pressure on workers, the platform has grown from 90,000 to 400,000 members in the last three months.Īsked if Organise is designed to be an alternative to unions or to work with them, Whalley says the platform is complementary to union activities and that many of its members are union members too. To date, Organise has enabled workers to mount successful campaigns against unjust working practices at companies including McDonald’s, Ted Baker, Amazon, Uber and Deliveroo. This might be through surveys, calls to sign petitions, or open letters to decision makers.” They decide what change they want and we provide the tools to make it happen. “Once part of the network, users are in control of their campaigns. For new campaigns, we can help people build up the awareness they need to get colleagues or workers from across their industry on board. “The platform is then able to connect employees to existing networks of people from the same organisation, immediately enabling them to speak with one, much louder voice. “When people join Organise, we ask them to share their workplace and employment status,” she says. Whalley explains that users discover Organise in one of three ways: they’re looking to change something in their workplace and discover Organise as a way to make that happen they join a campaign someone else in their workplace has already started or they join a campaign calling for a national-level change related to the world of work. Our platform empowers individuals, groups and workplaces, helping them to affect meaningful change.” ![]() We provide a way to bring workers together and give them the tools needed to make themselves heard. ![]() “When people run into issues around unsafe environments or concerns about unfair pay or maternity rights, they have nowhere to turn for support. “With so many people working remotely, it’s harder to share your problems with colleagues or raise issues about work,” says Whalley. And Hay was formerly the tech director at 38 Degrees, and also ran Amazon Anonymous, leading her to be dubbed “the thorn in Jeff Bezos’ side.” Whalley has a background in political campaigning at 38 Degrees and Avaaz, and also ran ChangeLab, a digital agency building campaigning technology. ![]() That makes sense, given its founders’ resumes. The idea is to combine the power of collective action, traditionally harnessed by trade unions, with the reach and insight of modern digital campaigns. The round is led by Ada Ventures, fitting into the VC firm’s remit to back “overlooked markets and founders.” Also participating is Form Ventures, RLC Ventures (a seed-stage fund that commits a portion of their profits back to charitable causes chosen by founders) and Ascension Ventures via its Fair By Design Fund.įounded in 2017 by CEO Nat Whalley and CTO Bex Hay, Organise describes itself as a “worker-driven network” that provides a range of digital tools and support to enable anyone to start a campaign to improve their working conditions. startup that has built a platform to help workers organise and campaign for better rights, has raised £570,000 in seed funding. ![]() Augmented Reality is any experience which is artificial and which adds to the already existing reality. Information about the environment and its objects is overlaid on the real world. adding computer vision, incorporating AR cameras into smartphone applications, and object recognition) the information about the surrounding real world of the user becomes interactive and digitally manipulated. With the help of advanced AR technologies (e.g. Īugmented reality is used to enhance natural environments or situations and offers perceptually enriched experiences. In education, content may be accessed by scanning or viewing an image with a mobile device or by using markerless AR techniques. Subsequently, augmented reality applications have spanned commercial industries such as education, communications, medicine, and entertainment. Commercial augmented reality experiences were first introduced in entertainment and gaming businesses. Air Force's Armstrong Laboratory in 1992. The earliest functional AR systems that provided immersive mixed reality experiences for users were invented in the early 1990s, starting with the Virtual Fixtures system developed at the U.S. The primary value of augmented reality is the manner in which components of the digital world blend into a person's perception of the real world, not as a simple display of data, but through the integration of immersive sensations, which are perceived as natural parts of an environment. There is also overlap in terminology with extended reality and computer-mediated reality. Īugmented reality is largely synonymous with mixed reality. In this way, augmented reality alters one's ongoing perception of a real-world environment, whereas virtual reality completely replaces the user's real-world environment with a simulated one. This experience is seamlessly interwoven with the physical world such that it is perceived as an immersive aspect of the real environment. additive to the natural environment), or destructive (i.e. The overlaid sensory information can be constructive (i.e. AR can be defined as a system that incorporates three basic features: a combination of real and virtual worlds, real-time interaction, and accurate 3D registration of virtual and real objects. The content can span multiple sensory modalities, including visual, auditory, haptic, somatosensory and olfactory. Air Force, Wright-Patterson Air Force Base (1992)Īugmented reality ( AR) is an interactive experience that combines the real world and computer-generated content. Not to be confused with Virtual reality or Alternate reality. ![]() Grab some compressed air if you don’t need to clean the blades or anything, but your blades are clogged with hair. Hit your blades with canned air if they’re sterilized but collecting dust. You may either soak the blade for a few minutes or give it a quick wipe clean and you’re ready to go! I. Pick up a professional clipper cleaner if you want to clean, cool, sanitize, and disinfect at the same time. There are professional “all-in-one” cleaners that sterilize and disinfect. Remove the blades and rinse them completely under cool water before wiping them dry with a clean cloth when you’re done. Submerge your clipper blades for at least 10 minutes after removing them. Fill a small cup or bowl with bleach and 2 cups (475 mL) of water. BleachĬlippers can be disinfected with a 1:10 solution of bleach and water. Then turn off the clippers and wipe away any remaining spray (3). ![]() Allow the blades to run for a few moments. Turn on the clippers, step back a few inches, and spray a small layer of the spray on the blade. Clipper cleaning sprays keep the blade cool while cleaning and sanitizing over extended use. If you’re in a rush, sprinkle the blades with clipper cooling spray and wipe them down. They remove excess hair and oil from the blade while also helping with heat dissipation. Clipper SprayĬlipper spray refers to any cleaning and cooling agent made specifically for your clippers. ![]() And now you have a sanitary and clean clipper blade! To remove any hair stuck to your blades, run the clipper into a small bowl of vinegar. Fill a cup with distilled white vinegar and soak your blade for about 30 seconds.Īfter that, pull it out and rinse it with water. You can also sanitize and disinfect your home with distilled white vinegar. The hair will quickly slide off into the liquid (2). You can also put some alcohol in a cap, turn on the clippers, and dip the blade tips into the alcohol. When you’re through, pull them out and rinse them to remove any leftover hair or alcohol residue. Grab a cup, fill it up enough with water, then submerge your blades for a minute or so. You may do it at home by soaking your blades in 70% isopropyl alcohol. This will properly clean and sanitize them. When you’re finished, rinse the clipper blades under water. ![]() Allow at least 10 minutes for your blades to soak. Want to know how to clean clipper blades at home In a glass cup or bowl, combine 1 fl oz (30 mL) Barbicide with 16 fl oz (470 mL) water to sterilize and clean your blades. You know that small blue liquid-filled container you see on barber’s counters? hat’s Barbicide-a sanitizing liquid for hair styling tools. Scrub the soap into the tips of the blades with a brush after rubbing the body of the blade down with your fingers or a cloth. If it’s your first cut of the day or you simply need to touch up something, soap and water will help.Īpply a dollop of grease-fighting dish soap to the blade and soak it in warm water. Soap and WaterĪ quick clean can be done by rubbing the blade with soapy water. You can also use a clean toothbrush or the specialty micro-brush if that’s all you’ve got on hand (1). To remove clumps of hair, simply drag the bristles back and forth on both sides of the blades. If you don’t have one, feel free to use any clean brush you have on hand. If you still have the brush that came with your clipper set, use it. This can be done with any stiff, clean brush. Brushīrush the blades a few times to get rid of all the hairs. If you want to know how to clean hair clippers at home, follow these clipper maintenance steps to keep them clean. |
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